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Neurological disorders pose substantial burdens on individuals families, and health systems.

Management of Neurological Disorders
Dr. Ghassan Shannan, BSc, PhD
Dean of the Faculty of Pharmacy
Arab International University
Damascus, Syria
Neurological disorders pose substantial burdens on individuals, families, and health
systems.
This presentation synthesizes current evidence-based strategies for the
management of four prevalent conditions: Alzheimer’s disease (AD), Parkinson’s
disease (PD), Multiple Sclerosis (MS), and epilepsy.
We review etiopathology-informed treatment paradigms, including disease-
modifying therapies where available, symptom-directed pharmacotherapy, non-
pharmacological approaches, and multidisciplinary care models.
For AD, we discuss cholinesterase inhibitors, NMDA receptor antagonists, and
emerging disease-modifying modalities, alongside cognitive rehabilitation and
caregiver support.
In PD, we highlight dopaminergic therapies, MAO-B and COMT inhibitors, non-
dopaminergic agents, deep brain stimulation in selected patients, and
rehabilitation.
MS management is covered through disease-modifying therapies, relapse
management, symptom control (spasticity, pain, fatigue), and rehabilitation to
optimize mobility and quality of life.
For epilepsy, we compare broad-spectrum antiseizure drugs, individualized
regimens, seizure safety, and strategies for drug-resistant epilepsy including
neuromodulation and surgical options.
Cross-cutting themes include early diagnosis, personalized medicine, patient-
centred care, telemedicine, and the integration of multidisciplinary teams. The talk
concludes with practical guidelines for clinicians to optimize outcomes across these
disorders while addressing access, adherence, and caregiver support